Targeted Nutrition to SlowCognitive Decline and BrainShrinkage

Improve Brain Health, Memory, Focus&Concentration

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    When Little Slips Start Adding Up

    Everyone forgets things now and then — a name, a date, where you left your keys. But when those slips start to happen more often, or daily life feels a little harder, it might be worth bringing up with your healthcare provider. Some additional signs you may notice include:

    • Missing appointments often

    • Struggling to find words

    • Frequently losing things

    • Losing train of thought

    • Having trouble deciding

    • Getting lost in familiar places

      Dual Action Formula

      Targeted nutrition for Mild Cognitive Impairment (MCI).

      Improves

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      Brain Health

      Cerefolin Brain Wellness™ helps support overall brain function by providing essential nutrients that aid in reducing harmful homocysteine levels, which can negatively impact brain health.3*

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      Memory & Focus

      Individuals taking Cerefolin Brain Wellness™ showed improvement in memory and ability to focus on daily activities.4*

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      Concentration

      Cerefolin Brain Wellness™ helped people maintain attention and stay on task, which are essential for completing daily tasks and decision-making processes.4*

      Slows

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      Cognitive Decline

      Long-term use of Cerefolin Brain Wellness™ was associated with a significantly slower rate of cognitive decline, especially in individuals with mild cognitive impairment.2*

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      Brain Atrophy

      Research shows that people with mild cognitive impairment (MCI) and elevated homocysteine who took Cerefolin Brain Wellness™ experienced slower brain shrinkage — helping support memory, thinking skills, and overall brain health.1*

      Trust in the Results

      Neurologists recommend Cerefolin Brain Wellness™*. Starting early can help protect your brain cells, slow the loss of brain function, and improve your overall quality of life.1-3

      Learn More

      Clinically Proven To

      Slow the rate of brain shrinkage by 11.2x1*

      Strong Loyalty

      94% who used product for 90 days said they planned to continue4*

      Free From

      Gluten, dyes, sugar, sodium, caffeine, preservatives, GMOs, titanium dioxide and major food allergens*

      You may start seeing improvements in as little as 45 days4

      • Many saw improvement inmood, memory, work lifebalance, and energy levels

      • Many saw improvement inquality of life and ability to learn,remember and understand 3-4

      • Many continue to experienceimprovements in memory andcognitive function

        Continue taking daily to help maintain long-term brain wellness

        What people are saying§||*

        • "i'm very appreciative of yourwonderful service and also yourgreat product." "l recommend itto everybody."
          -Tressie

        • "Those things really work." “i'mnot going to the refrigeratorlooking for ketchup andforgetting what l went to it for."
          -George

        • "| believe that CerefolinNAC®*helped me tremendously withmy day to day thinking.

          -Monica

        • " am feeling improvementsfrom taking CerefolinNACe*.""We have many good yearsahead of us to enjoy the activelives we lead."
          -Tessa

        • "This has been a night and daydifference. l feel like myself
          again."
          - Roland

        • "l am doing much better."

          - Laura

        • "I used to forget things a lot, butstill a little, but not like before.Before it was terrible.l wouldeven cry.l would get frustratedbecause my forgetfulness was
          so bad."
          -Cecelia

          What to Do If You Think You or Someone You Love Has MCI

          Cerefolin Brain Wellness™ is targeted nutrition in caplet form specially formulated to meet the distinctive nutritional requirements of individuals with MCI. Addressing certain underlying imbalances with this targeted nutrition may help you retain your ability to learn, remember, understand, and function longer. Starting as early as possible is important to help protect your brain health.

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          Disclaimers

          Cerefolin Brain Wellness™ is a targeted nutrition product for the clinical dietary management of mild cognitive impairment with hyperhomocysteinemia and is specially formulated to meet the distinctive nutritional requirements for this condition. Use under medical supervision.

          § Images don’t portray actual consumers and are for illustration purposes only.

          || Testimonials based on experience with CerefolinNAC®*.

          * Cerefolin Brain Wellness™, formerly known and studied as CerefolinNAC®, is the same trusted and effective product that is now free from major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame and soy), dyes, and colorants.

          † By submitting this information, I hereby give Alfasigma USA, Inc. authorization to release, reproduce, use or distribute information about me, in original or modified form, for promotional and educational purposes in all forms of media, including print, broadcast or Internet. This information may include my medical information if I choose to submit any. I understand my information may be shared with a third party working on Alfasigma USA, Inc.’s behalf for promotional or educational purposes. I also understand that I may be contacted by this third party or Alfasigma USA, Inc. for more information.

          †† This product should be taken under medical supervision, and you should consult your healthcare provider before taking this for mild cognitive impairment.

          References

          1. Shankle WR, et al. J Alzheimer’s Dis. 2016 Oct 4;54(3):1073-1084
          2. Shankle WR, et al. J Aging Res Clin Prac. 2013
          3. Hara J, et al. Nutr Health Aging. 2015
          4. Alfasigma USA. Data on File. PLUS Program: Patient Survey Results 2012. USA
          5. Data on file. Support data 2019-2024. Alfasigma USA.
          6. Chan A, et al. J Nutr Health Aging 2008;12(4):252-61.
          7. de Jager CA. et al. Int J Geriatr Psychiatry. 2012 Jun:27(6):592-600.
          8. Merrill E, et al. Am. J. Epidemiol. 2005 Oct;162(7):644-53.
          9. Altern Med Rev 2000 Oct;5(5):467-71.
          10. de Jager CA. Neurobiol Aging 2014;35(suppl 2):535-9.
          11. Atkuri KR, et al. Curr Opin Pharmacol. 2007. 2007
          12. N-acetylcysteine. Monograph. Alt Med Rev. 2000
          13. Antoniades C, et al. Circulation. 2006.
          14. Calderón-Ospina CA, et al. CNS Neurosci Ther. 2020.
          15. Kimura, A.M et al. Alzheimer’s Dement. 2021.
          16. Rogers JD, et al. Arch Neurol. 2003 Jan;60(1):59-64.
          17. Smith AD, et al. J Alzheimer’s Dis.
          18. Seshadri S, et al. N Engl J Med. 2002.
          19. Yao Y, et al. J Geriatr Cardiol. 2017.
          20. Diaz-Arrastia R, et al. Arch Neurol. 2000.
          21. Keller, A.C., et al. J. Appl. Physiol. 2019.
          22. Zhu Z, et al. Climacteric. 2020.
          23. Estrada, D.A. et al. Am. J. Hematol. 2001.
          24. Luzzi S, et al. Biomedicines. 2022.
          25. Diekman, M. J. M., et al. Clin. Endocrinol. (Oxf) 2001.
          26. Paknahad Z, et al. Int J Prev Med. 2012.
          27. Desouza, C, et al. Drugs. 2002.
          28. P. S. Myles et al. Br. J. Anaesth. 2008.
          29. Fallah S, et al. J Clin Lab Anal. 2012.
          30. Lerman, et al. AJMS., 2022.
          31. Troen AM, et al. Proc Natl Acad Sci U S A. 2003.
          32. Haj Mouhamed D, et al. Clin Chem Lab Med. 2011.
          33. Smith AD, et al. PLoS One, 2010.
          34. Douaud G, et al. Proc Natl Acad Sci U S A, 2013.
          35. Xu M, et al. J Evid Based Med. 2024.
          36. Sohouli MH, et al. Nutr Rev. 2024.